Biomedical scientists from the University of Central Florida and Louisiana State University have identified a way to block a “cell death signal” that they believe triggers brain damage during strokes.
Strokes, also known as cerebral ischemia, are caused by inadequate blood flow to the brain and are the third-leading cause of death in the United States.
The team’s work focused on a neurotransmitter that typically plays an important role in communication among nerve cells in the brain and fosters learning and memory. This glutamate neurotransmitter opens the NMDA (N-methyl-D-aspartate) receptors, allowing the entry of calcium into the nerve cells.
Under normal conditions, the activity of the NMDA receptors is tightly regulated to prevent nerve cells from becoming overloaded with calcium. During a stroke, however, that process of regulation breaks down. The excessive influx of calcium through NMDA receptors kills the nerve cells and can cause severe brain damage.
…read more about ‘Death Signal’ Can Be Blocked; Discovery May Aid Drug Development
